Theiler’s Murine Encephalomyelitis Virus-Induced Demyelinating Disease (TMEV-IDD) and Autoimmunity

摘要: Theiler's murine encephalomyelitis virus (TMEV) belongs to the Picornaviridae family and is a natural enteric pathogen of mice. Neurovirulence upon experimental intracerebral injection varies depending on strain TMEV ranging from rapidly fatal encephalitis, in which grey matter neurons are infected lysed infection with GDVII strain, an initial acute phase involvement followed by chronic viral persistence, inflammation, demyelination white spinal cord following BeAn or DA strains. TMEV-IDD well-characterized CD4 + T cell-mediated model Multiple Sclerosis (MS). Life-long persistent central nervous system (CNS) resident microglia, macrophages, astrocytes directly related development demyelinating disease. Initial myelin damage mediated bystander mechanism wherein primary effector cells mononuclear phagocytes (microglia/macrophages) activated inflammatory cytokines produced specific Thl responding epitopes that persist CNS. MS lesions have potential fully activate both naive memory within