Review article: drug-induced liver injury in clinical practice

摘要: Aliment Pharmacol Ther 2010; 32: 3–13 Summary Background  Drug-induced liver injury (DILI) is an important differential diagnosis in many patients clinical hepatology. DILI the leading cause of acute failure and safety issue when new drugs are developed. Aims  To provide a review recent data on with particular focus most common relevant issues seen practice. Methods  A Medline search was undertaken to identify literature using terms including ‘drug-induced injury’ ‘hepatotoxicity’. Results  The true incidence remains unknown but up 14 cases per 100 000 inhabitants year has been reported. Antibiotics, analgesics NSAIDs causing injury. Idiosyncratic shown have dose-dependent component without significant hepatic metabolism rarely DILI. Chronic elevation enzymes can develop after this associated morbidity or mortality. Conclusions  diagnostic challenge. Multicentre studies international collaborative work well-characterized will increase our understanding drugs. New therapies for resulting from needed.