Characterization of the Catalase-Peroxidase Gene (katG) and inhA Locus in Isoniazid-Resistant and -Susceptible Strains of Mycobacterium tuberculosis by Automated DNA Sequencing: Restricted Array of Mutations Associated with Drug Resistance
作者： James M. Musser , Vivek Kapur , Diana L. Williams , Barry N. Kreiswirth , Dick van Soolingen
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摘要: The catalase-peroxidase gene (katG) and a two-gene locus (inhA) containing mutations associated with resistance to isoniazid in Mycobacterium tuberculosis were sequenced 34 resistant 12 susceptible strains. Virtually all organisms had amino acid changes KatG or nucleotide substitutions upstream of inhA. A region katG encoding two acids frequently altered strains (residues Ser315 Arg463) the inhA 10 51 isoniazid-resistant isolates from Netherlands. Most (84%) lacked katG. Together, approximately 75% replacements at 315 463 All 16 bovis microti studied Leu463 rather than Arg463 KatG, an observation consistent hypothesis that is ancestral condition M. tuberculosis.
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