摘要: The leukocyte aggregation test (LAT) detects the in vitro adhesion of sensitized, but not nonimmune, recipient leukocytes onto donor kidney cell monolayers. specifically cell-mediated homograft immunity up to 15 days prior appearance clinical signs or alteration chemical indexes. presence a positive reaction always signified incipient rejection, which was usually controlled by intravenously administered, high-dose methylprednisolone sodium succinate (Solu-Medrol) therapy. There no instance treatment effectively reversed rejection negative test. One common form may be characterized LAT results, cellular infiltrate on renal biopsy specimen, and sensitivity
sci-hub.se 参考文章(28)
E. M. Nicholls, Aggregation of buffy-coat leucocytes. A simple, sensitive assay for cell-mediated immunity. Clinical and Experimental Immunology. ,vol. 17, pp. 673- ,(1974)
B D Kahan, L O Huang, B H Tom, M M Jakstys, Characteristics of the leucocyte-aggregation assay for cell-mediated immunity. Clinical and Experimental Immunology. ,vol. 20, pp. 131- 141 ,(1975)
Milda M. Jakstys, Baldwin H. Tom, Barry D. Kahan, Leukocyte Aggregation: An in Vitro Assay for Cell-Mediated Immunity Journal of Immunology. ,vol. 113, pp. 1288- 1295 ,(1974)
E.A.J.M. Goulmy, A. Termijtelen, J.J. van Rood, J.J. Keuning, M.L. Bach, A. Blussé van Oud Alblas, J.G. van den Tweel, Typing for MLC (LD)) : I. Lymphocytes from cousin-marriage offspring as typing cells Transplantation Proceedings. ,vol. 5, pp. 1535- 1538 ,(1973)
Jerry C. Rosenberg, James J. Lightbody, Antibody-dependent cell-mediated cytotoxicity in prospective kidney transplant recipients. Journal of Immunology. ,vol. 112, pp. 890- 896 ,(1974)
S. Al-Askari, John R. David, H. S. Lawrence, L. Thomas, DELAYED HYPERSENSITIVITY IN VITRO. I. THE SPECIFICITY OF INHIBITION OF CELL MIGRATION BY ANTIGENS. Journal of Immunology. ,vol. 93, pp. 264- 273 ,(1964)
R. B. Markham, A. White, A. L. Goldstein, Selective Immunosuppressive Activity of Steroids in Mice Inoculated with the Moloney Sarcoma Virus Experimental Biology and Medicine. ,vol. 148, pp. 190- 193 ,(1975) , 10.3181/00379727-148-38503
Thomas F. Dougherty, G. L. Schneebeli, THE USE OF STEROIDS AS ANTI-INFLAMMATORY AGENTS Annals of the New York Academy of Sciences. ,vol. 61, pp. 328- 348 ,(1955) , 10.1111/J.1749-6632.1955.TB42483.X
R F M Wood, Aileen C. Gray, J D Briggs, P R F Bell, The prediction of acute rejection in human renal transplantation using the leucocyte migration test. Transplantation. ,vol. 16, pp. 41- 45 ,(1973) , 10.1097/00007890-197307000-00008
R FERRARESI, W ROOKSII, G NAKANO, H RINGOLD, C KIDSON, A selective inhibitor of the elicitation of immune-mediated reactions. The Journal of Allergy and Clinical Immunology. ,vol. 55, pp. 25- 34 ,(1975) , 10.1016/S0091-6749(75)80005-4