Synthesis of pH-responsive chitosan nanocapsules for the controlled delivery of doxorubicin.
作者： Chih-Kuang Chen , Qing Wang , Charles H. Jones , Yun Yu , Hanguang Zhang
DOI: 10.1021/LA4040485
关键词:
摘要: Well-defined chitosan nanocapsules (CSNCs) with tunable sizes were synthesized through the interfacial cross-linking of N-maleoyl-functionalized (MCS) in miniemulsions, and their application delivery doxorubicin (Dox) was investigated. MCS prepared by amidation reaction CS maleic anhydride water/DMSO at 65 °C for 20 h. Subsequently, thiol–ene conducted oil-in-water miniemulsions room temperature under UV irradiation 1 h, using as both a surfactant precursor polymer, 1,4-butanediol bis(3-mercapto-propionate) cross-linker, d-α-tocopheryl poly(ethylene glycol) 1000 succinate cosurfactant. With increase cosurfactant concentration systems, resulting CSNCs decreased steadily. Dox-loaded readily situ encapsulation Dox during miniemulsion cross-linking. acid-labile β-thiopropionate cross-linkages, demonstrated faster release rate u...
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