Simvastatin-induced up-regulation of gap junctions composed of connexin 43 sensitize Leydig tumor cells to etoposide: An involvement of PKC pathway
作者： Lingzhi Wang , Yanni Fu , Jianxin Peng , Dengpan Wu , Meiling Yu
DOI: 10.1016/J.TOX.2013.08.013
关键词:
摘要: Some of lipophilic statins have been reported to enhance toxicities induced by antineoplastic agents but the underling mechanism is unclear. The authors investigated involvement Cx43-mediated gap junction intercellular communication (GJIC) in effect simvastatin on cellular toxicity etoposide this study. results showed that a major component cytotoxicity therapeutic levels mediated junctions composed connexin 43(Cx43) and at dosage which does not induce enhances increasing coupling. augmentative GJIC was related inhibition PKC-mediated Cx43 phosphorylation ser368 subsequent enhancement membrane location agent. present study suggests possibility upregulation may be utilized increase efficacy anticancer chemotherapies.
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