Mitochondria-Mediated Oxidative Stress and Cancer Therapy

摘要: Most cancer cells demonstrate increased rates of glucose metabolism when compared to normal cells. Glucose leads the formation pyruvate and NADPH both which function in cellular detoxification hydroperoxides. Therefore, tumor may increase their as a compensatory mechanism protect against hydroperoxides generated byproducts mitochondrial metabolism. Recent studies have shown that deprivation preferentially induces cytotoxicity oxidative stress human cells, relative Mitochondria been hypothesized be site prooxidant production during deprivation. The preferential seen has implications designing more effective combined modality therapies involving inhibitors glycolytic agents enhance ROS production. Many drugs currently used treat (i.e., ionizing radiation, Cisplatin, Doxorubison, azidothymidine, etc.) proposed superoxide hydrogen peroxide could also with detoxification. application these findings developing new therapy protocols will discussed well clinical using FDG-PET imaging predict responses therapy.