Filament-anchored hydrogel layer on polypropylene hernia mesh with robust anti-inflammatory effects.
作者： Lu Wang , Yan Li , Qian Zhang , Yansha Qiao , Qian Wang
DOI: 10.1016/J.ACTBIO.2021.04.013
关键词:
摘要: The efficacy of implanted polypropylene (PP) hernia meshes is often compromised by an inflammatory response. Thus, engineering an anti-inflammatory mesh has significant implications for hernioplasty. Here, we report a facile strategy to develop a filament-anchored hydrogel layer (FAHL) on PP mesh (FAHL-P). The network of FAHL, made up of chondroitin sulfate and gelatin (CG), provided a biomimetic surface with immunoregulatory properties. The use of tannic acid (TA) as a crosslinker for CG additionally enhanced its anti …
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