Effects of alpha 1- and alpha 2-adrenoceptor stimulation and blockade on plasma insulin levels in the mouse

摘要: Stimulation of alpha-adrenoceptors is known to inhibit insulin secretion under a variety conditions. In this study, the question whether these are alpha 1- or 2-subtype was investigated in mouse. The selective 2-adrenoceptor agonist clonidine (0.05-50 nmol/kg) found markedly secretory response both glucose and cholinergic carbachol. This inhibition counteracted by antagonist yohimbine (2.6 mumol/kg), but not 1-adrenoceptor prazosin mumol/kg). contrast, phenylephrine did affect either Moreover, increased basal plasma levels. It concluded that blockade followed enhancement levels mouse, whereas stimulation impairs