The diabetic macroangiopathy considered from a vascular biological point of view Hyaluronic acid and its receptor's (CD44) formation and influence on the vessel wall.

摘要: The studies behind this thesis were carried out at the Laboratory of Biochemical Pathology, Arhus Sygehus. is based on an original paper investigating effects diabetic-like concentrations components metabolic disorders diabetes mellitus. In 1971 term diabetic macroangiopathy was introduced to emphasize presence non-atherosclerotic large vessel disease in patients. Diabetic does not indicate a set abnormalities restricted certain areas vessels as atherosclerosis, but number specific wall changes seen entire system. These are regarded be consequence metabolism. aorta without atherosclerotic plaque increased proportion HA observed tunica media individuals. Furthermore receptor, CD44, induced vascular SMCs after arterial injury and may mediate proliferation migration into intima. Thereby its receptor CD44 important factor pathogenesis cardiovascular aim evaluate influence glucose, insulin, IGF-1 hGH expression CD44std variant isoforms CD44v3 CD44v6 vitro. effect – like four SMC examined determine whether for migration. conclusion, these vitro confirm that plays role insulin IGF-1. Therefore might contribute accumulation intima patients with diabetes. results support notion have significant binding thereby modulating function during development subjects. Finally showed small manipulation some components.