Corticotropin-releasing factor receptors: an overview.

摘要: Corticotropin-releasing factor (CRF) is the primary physiological regulator of basal and stress-induced release ACTH, beta-endorphin other POMC-derived peptides from pituitary plays a major role in brain periphery coordinating endocrine, electrophysiological, autonomic, behavioral immune responses to stress. In addition, recent clinical data implicate CRF etiology pathophysiology variety psychiatric neurodegenerative disorders. The various effects are mediated by two distinct receptors expressed at high levels selected areas, but also different several non-neuronal tissues. This chapter provides an overview current knowledge about including tissue specificity regulatory aspects as well molecularbiological, biochemical pharmacological characteristics. neuroimmune, neuroendocrine behavioral-related implications receptor its involvement disorders discussed. review summarizes four decades research beginning with search for that governs ACTH getting findings successful cloning subtypes discovery new endogenous CRF-related ligand.