1 Identification of Tumor-Specific Genes

摘要: This chapter discusses the identification of tumor-specific genes. Tumors result from perturbation processes that control normal growth, localization, and mortality cells. The loss mechanisms arises acquisition mutation in three broad categories genes— namely, protooncogenes, tumor-suppressor genes, deoxyribonucleic acid (DNA) enzymes. There are two approaches used tumor-associated antigens (TAAs): (1) use already existing immunologic response a tumor patient to identify TAAs (2) combination molecular biology biochemistry, with characterization techniques. first approach is based on humoral (B cell) or cellular has advantage that, beginning, it known an immune against TAA possible. second initially uses more statistical setting requires proof selected putative target proteins can be for generation patients. Some other response, such as serologic analysis autologous Antigen, by recombinant complementary DNA (cDNA) expression cloning (SEREX), reverse immunology, transcription profiling, differential ribonucleic also discussed chapter.