A Randomized, Placebo-Controlled Study of the Impact of the 7-Day Buprenorphine Transdermal System on Health-Related Quality of Life in Opioid-Naïve Patients With Moderate-to-Severe Chronic Low Back Pain

摘要: Abstract This study evaluated the impact of treatment with Buprenorphine Transdermal System (BTDS) on health-related quality life for patients moderate-to-severe chronic low back pain (CLBP), and correspondence between pain. A multicenter, enriched, double-blind (DB), placebo-controlled, randomized trial BTDS 10 20 μg/hour opioid-naive CLBP. The SF-36v2 survey, which measures 8 domains life, was administered at screening following an open-label run-in period weeks 4, 8, 12 DB phase. Post hoc analyses compared scores placebo groups during Condition burden examined through comparisons a U.S. general population sample. Correlations measures. produced larger improvements than in all quality-of-life ( P s Perspective post analysis suggests that CLBP treated exhibit better those using within 4 treatment, were more likely to clinically meaningful treatment.