The effect of extent of resection on recurrence in patients with low grade cerebral hemisphere gliomas

摘要: Background. To evaluate the role of radical resection for low grade cerebral hemisphere gliomas, authors analyzed preoperative and postoperative radiographic tumor volumes (computed tomography hypodensity, magnetic resonance imaging-T2 signal hyperintensity) in 53 patients. Methods. Using a previously described method computerized image analysis, evaluated whether percent volume residual disease, postoperatively, influenced incidence recurrence, time to progression, histology recurrent tumor. Survival was not this study. Results. No recurrence detected, regardless patients with less than 10 cm3 (mean follow-up, 41.7 months). Patients tumors measuring 10-30 had an progression 13.6% 58 months, respectively, compared greater 30 cm3, which 41.2% respectively (P = 0.016). All (n 13) who underwent 100% recurrence-free follow-up period (mean, 54 In remaining 40), as decreased, increased along shorter 0.03). disease higher (46.2%) (30 months) (incidence 14.8% 50 0.002). Forty-six more histologic grade, significantly frequent (3.7%) 0.0009). Age, radiotherapy, subtype no influence on patterns. Conclusion. For authors' data suggest that smaller conveys significant advantage, is, terms phenotype, those have aggressive or biopsy. While may also be case further is necessary determine effect surgery patterns subset patients.