Splice Variants of the RTK Family: Their Role in Tumour Progression and Response to Targeted Therapy.

摘要: Receptor tyrosine kinases (RTKs) belong to a family of transmembrane receptors that display kinase activity and trigger the activation downstream signalling pathways mainly involved in cell proliferation survival. RTK amplification or somatic mutations leading their constitutive oncogenic properties have been reported various tumour types. Numerous RTK-targeted therapies developed counteract this hyperactivation. Alternative splicing pre-mRNA has recently emerged as an important contributor cancer development maintenance. Interestingly, RTKs are alternatively spliced. However, biological functions splice variants, well upstream signals control expression tumours, remain be understood. More importantly, it remains determined whether, how, these events may affect response cells therapies, inversely, whether impact events. In review, we will discuss role alternative progression with special focus on two major proliferation, survival, angiogenesis, namely, epidermal growth factor receptor (EGFR) vascular endothelial receptor-1 (VEGFR1).