Modulation of Myostatin/Hepatocyte Growth Factor Balance by Different Hemodialysis Modalities.

摘要: Background. In this study we investigated the relevance of myostatin and Hepatocyte Growth Factor (HGF) in patients undergoing hemodialysis HD influence different modalities on their levels. Methods. We performed a prospective crossover which were randomized to undergo 3-month treatment periods with bicarbonate (BHD) followed by online hemodiafiltration (HDF). Clinical data, laboratory parameters, HGF serum levels collected compared. Results. Ten six controls (C) evaluated. any experimental condition higher than C. At enrollment after BHD there not significant correlations, whereas at end HDF period inversely correlated ( , ), transferrin that resulted positively BMI 0.67, ). Moving from HDF, clinical parameters unchanged, as well HGF, significantly decreased (6.3 ± 4.1 versus 4.3 3.1 ng/ml, Conclusions. Modulation myostatin/HGF balance use might represent novel approach prevention HD-related muscle wasting syndrome.