Urinary p-tyramine in hereditary tyrosinemia: II. Origin of urinary p-tyramine
作者： Gordon N. Hoag , Alan Hill , Witold Zaleski
DOI: 10.1016/S0009-9120(77)90406-4
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摘要: 1. A patient with hereditary tyrosinemia (tyrosinosis) was given oral loads of p-tyramine and tyrosine without medication (neomycin) to investigate the respective roles intestinal bacteria tissues in accounting for origin urinary p-tyramine. 2. The excretion a high circulating level following an load as conjugated p-hydroxyphenylacetic acid (p-HPAA) 3. Both bacterial activity tissue decarboxylation appeared account this tyrosine. 4. Sterilization gut by neomycin second further supported predominate role 5. data suggested that major route metabolism man may be via
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