Using High Spectral and Spatial Resolution Bold MRI to Choose the Optimal Oxygenating Treatment for Individual Cancer Patients

摘要: We evaluate whether high spectral and spatial resolution (HiSS) BOLD MRI can correctly rank the effects of three tumor-oxygenating treatments on radiosensitivity in BA1112 rhabdomyosarcomas (n = 5). Significant decreases linewidth predict that treatment with carbogen gas combined a perfluorocarbon emulsion will increase more than either alone, which agrees known these hypoxic fraction. High-resolution maps show tumor response to each is spatially heterogeneous, there paradoxical 7 – 12% pixels. Because HiSS emphasizes changes necrotic and/or hemorrhagic regions, it sensitive oxygenation compared conventional MRI. These results demonstrate practical, noninvasive method could be used choose maximizes size extent increases for individual patients.