Does cirrhosis affect quality of life in hepatitis C virus-infected patients?

摘要: Background: Hepatitis C virus (HCV) infection is a major cause of chronic liver disease and associated with impairments in health-related quality life. Aims: To evaluate life (QOL) cirrhotic (compensated decompensated) non-cirrhotic patients HCV infection, using preference-based (utilities) nonpreference-based methods evaluating QOL. Methods: In tertiary care setting, 271 completed self-administered time trade-off utility instrument, the Health Utility Index Mark 2 3, Quality Life Questionnaire Version 2. Mean QOL scores were compared across stages sociodemographical categories. We examined association between stage linear regression adjusting for age, education, marital status, log income Charlson comorbidity scores. propensity score method. Results: utilities lower than general population norms (0.81–0.92) ranged from 0.62 to 0.82 (n = 197), 0.56–0.84 compensated 17) 0.55–0.76 decompensated 57). No significant found was current health status. Higher income, fewer comorbidities living married or common-law relationship significantly higher better difference matching. Conclusions: Our study confirms that changes explain only small suggests factors such as underlying comorbidities, status have greater effect on stage.