Importance of neutrophils in the pathogenesis of acute pneumonic pasteurellosis in calves

摘要: Acute lung injury was induced in 24 calves by intratracheal inoculation with Pasteurella haemolytica. Calves groups 1 and 2 were neutrophil depleted, using hydroxyurea given IV. Group (n = 7) inoculated intratracheally saline solution, group P 3 had normal numbers of neutrophils 4 3) treated acutely IV, neutrophils, After inoculation, (groups 4) became hypoxemic hours after hypoxemia persisted until necropsy (6 inoculation). These also developed tachypnea, bradycardia, neutropenia, lymphopenia. Lung lesions consisted necrosis the alveolar walls, intra-alveolar hemorrhage, a severe exudative necrotizing bronchopneumonia, accumulation proteinaceous fluid alveoli lymphatics. In neutrophil-depleted 2), blood gas values, heart respiratory rates, circulating leukocytes did not change solution or At necropsy, lungs grossly normal. Therefore, required for acute The protective effect depletion specific because high concentrations (group injury.