Farnesyltransferase and Geranylgeranyltransferase Inhibitors
作者： James J. Fiordalisi , Adrienne D. Cox , Channing J. Der , Kelley Rogers-Graham , L. Gerard Toussaint
DOI: 10.1007/978-1-59259-013-1_17
关键词:
摘要: Since 1982, when mutated and oncogenic forms of ras genes were first identified in human tumor cells, their protein products have attracted considerable interest as a target for anticancer drug development. Researchers inspired to delineate the functions Ras proteins normal cells determine how altered these functions. The impressive accumulation information about genetics, biochemistry, biology, structure over last 17 years has provided important clues anti-Ras drugs may be developed.
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