摘要: In the past few decades, gene regulatory networks and cellular signaling have been regarded as major systems in a cell. contrast, RNAs thought molecules which are only transferring genetic information for protein production. Recently, microRNAs (miRNAs) emerged another layer of regulation. They regulate many key biological processes, including cell growth, death, development differentiation. This discovery hints that cells more complicated regulation systems. Genes working together by forming networks. It has become an emerging concept miRNAs could intertwine with to exert their function. Thus, it is essential understand how take part processes at systems-level. this chapter, I will summarize most recent progress understanding miRNA biology systems-level: principles signaling, metabolic, interaction A common principle emerging: preferentially regulated genes high complexity. addition, positive loops, highly connected scaffolds network downstream components networks, while selectively specific structural features on metabolic
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