Applied Concepts in PBPK Modeling: How to Build a PBPK/PD Model.
作者： L Kuepfer , C Niederalt , T Wendl , J‐F Schlender , S Willmann
DOI: 10.1002/PSP4.12134
关键词:
摘要: … concepts of PBPK/PD models, focusing on their practical implementation in a typical PBPK model … This model is implemented in the PK-Sim software as the PK-Sim standard distribution …
sci-hub.se 参考文章(99)
Andrea N Edginton, Stefan Willmann, Physiology-based simulations of a pathological condition: prediction of pharmacokinetics in patients with liver cirrhosis. Clinical Pharmacokinectics. ,vol. 47, pp. 743- 752 ,(2008) , 10.2165/00003088-200847110-00005
Victor A. Levin, Doug Dolginow, Herbert D. Landahl, Craig Yorke, Judit Csejtey, Relationship of octanol/water partition coefficient and molecular weight to cellular permeability and partitioning in s49 lymphoma cells. Pharmaceutical Research. ,vol. 1, pp. 259- 266 ,(1984) , 10.1023/A:1016393902123
Angelika Loidl‐Stahlhofen, Thorsten Hartmann, Matthias Schöttner, Cornelia Röhring, Hanna Brodowsky, Johannes Schmitt, Jörg Keldenich, Multilamellar liposomes and solid-supported lipid membranes (TRANSIL): screening of lipid-water partitioning toward a high-throughput scale. Pharmaceutical Research. ,vol. 18, pp. 1782- 1788 ,(2001) , 10.1023/A:1013343117979
C Wagner, P Zhao, Y Pan, V Hsu, J Grillo, SM Huang, V Sinha, Application of Physiologically Based Pharmacokinetic (PBPK) Modeling to Support Dose Selection: Report of an FDA Public Workshop on PBPK. CPT: Pharmacometrics & Systems Pharmacology. ,vol. 4, pp. 226- 230 ,(2015) , 10.1002/PSP4.33
Vikash Kumar Sinha, Jan Snoeys, Nancy Van Osselaer, Achiel Van Peer, Claire Mackie, Donald Heald, From preclinical to human - prediction of oral absorption and drug-drug interaction potential using physiologically based pharmacokinetic (PBPK) modeling approach in an industrial setting: a workflow by using case example Biopharmaceutics & Drug Disposition. ,vol. 33, pp. 111- 121 ,(2012) , 10.1002/BDD.1782
Jennifer B. Dressman, Gordon L. Amidon, Christos Reppas, Vinod P. Shah, Dissolution Testing as a Prognostic Tool for Oral Drug Absorption: Immediate Release Dosage Forms Pharmaceutical Research. ,vol. 15, pp. 11- 22 ,(1998) , 10.1023/A:1011984216775
M. D. Harwood, S. Neuhoff, G. L. Carlson, G. Warhurst, A. Rostami-Hodjegan, Absolute abundance and function of intestinal drug transporters: a prerequisite for fully mechanisticin vitro-in vivoextrapolation of oral drug absorption Biopharmaceutics & Drug Disposition. ,vol. 34, pp. 2- 28 ,(2013) , 10.1002/BDD.1810
David G Levitt, Physiologically based pharmacokinetic modeling of arterial – antecubital vein concentration difference BMC Clinical Pharmacology. ,vol. 4, pp. 2- 2 ,(2004) , 10.1186/1472-6904-4-2
T Shepard, G Scott, S Cole, A Nordmark, F Bouzom, Physiologically Based Models in Regulatory Submissions: Output From the ABPI/MHRA Forum on Physiologically Based Modeling and Simulation. CPT: Pharmacometrics & Systems Pharmacology. ,vol. 4, pp. 221- 225 ,(2015) , 10.1002/PSP4.30
George M. Grass, Stephanie A. Sweetana, In vitro measurement of gastrointestinal tissue permeability using a new diffusion cell. Pharmaceutical Research. ,vol. 5, pp. 372- 376 ,(1988) , 10.1023/A:1015911712079