Spinal Dynorphin and Neuropathic Pain
作者： Josephine Lai , Ruizhong Wang , Frank Porreca
DOI: 10.1007/978-1-4419-0226-9_16
关键词:
摘要: The endogenous neuropeptides dynorphins are proteolytic products of prodynorphin which characterized by their high affinity for opioid receptors. Dynorphin A is widely distributed in the CNS and spinal cord found predominantly neurons laminae I/II V. Intrathecal dynorphin displays non-opioid activities can be reversed NMDA antagonists as well bradykinin B2 receptor antagonists. levels expression easily perturbed; elevated essential chronic pain. Descending modulatory pain pathways from rostral ventromedial medulla contribute to up-regulation maintenance neuropathic Recovery may depend not only on recovery peripheral injury but also reversing injury-induced adaptive changes central nervous system such up-regulation.
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