The role of the microbiota in sedentary lifestyle disorders and ageing: lessons from the animal kingdom.

摘要: A paradox of so-called developed countries is that, as the major historical causes human mortality are eliminated or mitigated by medical progress, lifestyle-related diseases have become killers. Furthermore, lifespan extended combined effects modern medicine, health span struggling to keep apace because burden noncommunicable linked diet and sedentary lifestyle. The gut microbiome now recognized a plastic environmental risk factor for many these diseases, being defined complex community co-evolved commensal microbes that breaks down components diet, modulates innate immunity, produces signalling molecules metabolites can impact on diverse regulatory systems in mammals. Aspects 'Western' lifestyle disease such energy dense antibiotic treatment known affect composition function microbiome. Here, we review detailed mechanisms whereby may modulate ageing-related loss. We focus comparative value natural animal models hibernation studying metabolic regulation challenge extrapolating from processes occur ageing.