Treatment of Acute Falciparum Malaria With Sulfalene and Trimethoprim

摘要: The combination of a long-acting sulfonamide, sulfalene, and dihydrofolic acid reductase inhibitor, trimethoprim, proved to be effective as radical cure against normal, well chloroquine-quinine-pyrimethamine-resistant Plasmodium falciparum in nonimmune volunteers. malaria caused by normal P was cured (eight eight cases) sulfalene (0.25 gm) plus trimethoprim (0.125 administered single dose. Sulfalene (0.75 (0.5 combined ten 11 patients with chloroquine-pyrimethamine-quinine-resistant . Attempts induce resistance the have been unsuccessful thus far. speed action clearance parasites lysis fever compares favorably that chloroquine at its best. is easily tolerated