Effects of norepinephrine, theophylline and dibutyryl cyclic AMP on in vitro lipolysis of human adipose tissue in obesity.
作者： F. A. Gries , M. Berger , M. Neumann , H. Preiss , H. Liebermeister
DOI: 10.1007/BF01235630
关键词:
摘要: Lipolysis (release of glycerol and free fatty acids) subcutaneous human adipose tissuein vitro has been investigated in relation to relative body weight fat cell size. Studying 86 persons, there was a highly significant logarithmic between weight, size lipid content tissue obtained from the abdominal region. Even extreme obesity mean diameter 135 μ generally not exceeded. In these cases overweight is due hypertrophy as well hyperplasia tissue. — The basal FFA release, calculated on basis content, did significantly differ normal persons. lipolysis individual increased, however, with increasing diameter. quotient resterification (FFA release: release) lower obesity. When stimulated norepinephrine, theophylline or dibutyryl-cyclic AMP, dose response relations were similar weight. stimulation lipolysis, expressed % baseline, diminished Stimulation dibutyryl-cyclic-AMP negatively correlated absolute release metabolites per after AMP positively Addition glucose resulted an increment inhibition release. However, correlation affected. observations suggest that large cells are provided additional total lipase. Under conditions inactive pro lipase active seemed change favour enzyme.
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