Pulmonary lymphomatoid granulomatosis. Evidence for a proliferation of Epstein-Barr virus infected B-lymphocytes with a prominent T-cell component and vasculitis.

摘要: Similarities have been noted in the histologic patterns of lymphomatoid granulomatosis and Epstein-Barr virus associated lymphoproliferative disease involving lung. has also identified by polymerase chain reaction most cases granulomatosis; however, precise cellular localization sequences not extensively studied. We analyzed 10 lung immunohistochemistry combined with situ hybridization for virus, CD20, CD45RO. All were selected from files Armed Forces Institute Pathology met clinical criteria diagnosis granulomatosis, grades 1 through 3. In all cases, showed that cells--small to medium-sized lymphocytes--were T cells (CD45RO+); a much smaller population large atypical B (CD20+). each case, confirmed presence within (CD20+) absence T-cells (CD45RO+). Polymerase analysis immunoglobulin heavy-chain gene rearrangement monoclonal pattern six nine tested, whereas T-cell receptor gamma-chain rearrangements was negative three tested. On basis these findings, we hypothesize represent proliferation infected B-cells prominent vasculitis, distinguishing angiocentric "T-cell lymphomas" other sites, such as head neck.