SYNTHESIS OF THE NEW MONOMER 3-(N-PYRIMIDIN-2-YL-N(-4-ACETYLAMINO-BENZENESULFONYL)AMINO-1-PROPENE, ITS COPOLYMERIZATION WITH MALEIMIDE AND HYDROLYSIS OF COPOLYMER
作者： Zhaoliang Lin , Lianjun Shi , Junlian Huang
DOI: 10.1081/MA-100101090
关键词:
摘要: A new monomer, 3-(N-pyrimidin-2-yl-N(-4-acetylaminoben-zenesulfonyl)amino-1-propene(PABP) (M1), was prepared using sulfadiazine as parent compound, and characterized by IR 1H-NMR in detail. It reluctant to homopolymerize, but could be copolymerized with maleimide (MI) (M2) dimethylformamide at 60°C AIBN an initiator. The copolymerization rate monomer conversion decreased increase of PABP contents feed ratio because the chain transfer propagation species PABP. After hydrolysis 15% HCl, copolymer bearing a pendant obtained.
sci-hub.se 参考文章(14)
Juan Bartulin, Michael Przybylski, Helmut Ringsdorf, Helmut Ritter, Pharmacologically active polymers, 6. Sulfadiazine and boron derivatives as potential carriers for polymers into cancer tissue Macromolecular Chemistry and Physics. ,vol. 175, pp. 1007- 1010 ,(1974) , 10.1002/MACP.1974.021750327
George Abel, Thomas A. Connors, Volker Hofmann, Helmut Ringsdorf, Pharmacologically active polymers, 13. Elucidation of the tumour affinity of poly[sulfadiazineacrylamide] Macromolecular Chemistry and Physics. ,vol. 177, pp. 2669- 2674 ,(1976) , 10.1002/MACP.1976.021770909
N. Calvert, T.A. Connors, W.C.J. Ross, Aryl-2-halogenoalkylamines European Journal of Cancer (1965). ,vol. 4, pp. 627- 636 ,(1968) , 10.1016/0014-2964(68)90047-9
Zhaohua Huang, Sheng Chen, Junlian Huang, Functionalization of Polyethylene Oxide with 4-Amino- N-(2-pyrimidinyl) Benzene Sulfonamide at One End Journal of Applied Polymer Science. ,vol. 73, pp. 1379- 1385 ,(1999) , 10.1002/(SICI)1097-4628(19990822)73:8<1379::AID-APP4>3.0.CO;2-3
WILLIAM REGELSON, STEPHAN KUHAR, MARVIN TUNIS, JOSEPH FIELDS, JOHN JOHNSON, EARL GLUESENKAMP, Synthetic polyelectrolytes as tumour inhibitors. Nature. ,vol. 186, pp. 778- 780 ,(1960) , 10.1038/186778A0
Gi-Cheol Kim, Jin-Gon Jeong, Neung-Ju Lee, Chang-Sik Ha, Won-Jei Cho, Synthesis and Biological Activities of Endo-3,6-Epoxy-1,2,3,6-Tetrahydrophthalimide and Its Polymers Journal of Applied Polymer Science. ,vol. 64, pp. 2605- 2612 ,(1997) , 10.1002/(SICI)1097-4628(19970627)64:13<2605::AID-APP14>3.0.CO;2-Y
Von O. F. Solomon, B. S. Gotesman, Zur berechnung der viskositätszahl aus einpunktmessungen Die Makromolekulare Chemie. ,vol. 104, pp. 177- 184 ,(1967) , 10.1002/MACP.1967.021040119
Barry D. Dean, Styrene/N‐phenylmaleimide copolymer miscible blends Journal of Applied Polymer Science. ,vol. 33, pp. 2259- 2261 ,(1987) , 10.1002/APP.1987.070330634
G. Abel, T.A. Connors, W.C.J. Ross, Nguyen-Hoang-Nam, H. Hoellinger, L. Pichat, The selective concentration of sulphadiazine and related compounds in malignant tissue European Journal of Cancer (1965). ,vol. 9, pp. 49- 54 ,(1973) , 10.1016/0014-2964(73)90042-X
Gi-Tak Gam, Jin-Gon Jeong, Neung-Ju Lee, Young-Woo Lee, Chang-Sik Ha, Won-Jei Cho, Synthesis and biological activities of copolymers of N‐glycinyl maleimide with methacrylic acid and vinyl acetate Journal of Applied Polymer Science. ,vol. 57, pp. 219- 225 ,(1995) , 10.1002/APP.1995.070570210