Helicobacter pylori is invasive and it may be a facultative intracellular organism.

摘要: The pathogenicity of many bacteria colonizing the gastrointestinal tract often depends on their ability to gain access cells that are normally non-phagocytic. Helicobacter pylori colonizes stomach over half world population and is main cause peptic ulcer disease gastric cancer. It generally considered be a non-invasive pathogen present only in lumen attached epithelial although number vivo vitro studies have demonstrated H. fact invasive. In addition, can repopulate extracellular environment after complete elimination with gentamicin, suggesting it may facultative intracellular bacterium. This review examines validity these observations describes evidence presence plays role induction diseases, immune evasion, life-long persistence bacterium majority humans.