Antimycobacterial Butanolides from the Root of Lindera akoensis
作者： Su-Yen Chang , Ming-Jen Cheng , Chien-Fang Peng , Hsun-Shuo Chang , Ih-Sheng Chen
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摘要: Three racemic butanolides, majorenolide (1), majorynolide (2), and majoranolide (3), with 18 known compounds, including ten i.e., litsenolide A(2) (4), B(2) (5), C(1) (6), C(2) (7), hamabiwalactone A (8), B (9), litseakolide (10), (11), isoobtusilactone (12), obtusilactone (13); one lignan, (+/-)-syringaresinol (14), two flavans, (+)-catechin (15), (-)-epicatechin (16), coumarin, scopoletin (17), four steroids, a mixture of beta-sitosterol (18) stigmasterol (19), beta-sitosteryl-3-O-beta-D-glucoside (20) stigmasteryl-3-O-beta-D-glucoside (21) were isolated from the root Lindera akoensis. The structures isolates elucidated by in-depth spectroscopic analysis. Compounds 1-3 previously assigned delta-lactone structure, which was then revised to gamma-lactone based on 1D-NMR data. cigar-HMBC technique used confirm accuracy zero [alpha] (20)_D value compounds suggested that they considerably racemized. Nine butanolides 1-3, 4-8, 10 showed antimycobacterial activities against M. tuberculosis H(37)Rv, MIC values 15-50 microg/ml.
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