Building Biomimetic Potency Tests for Islet Transplantation.

摘要: Diabetes is a disease of insulin insufficiency, requiring many to rely on exogenous with constant monitoring avoid fatal outcome. Islet transplantation recent therapy that can provide independence, but the procedure still limited by both availability human islets and reliable tests assess their function. While stem cell technologies are poised fill shortage transplantable cells, better methods needed for predicting To ensure islet quality, we propose next generation potency should be biomimetic systems match glucose stimulation dynamics microenvironmental preferences rapidly conditional continuous secretion minimal manual handing. Here, review current approaches testing outline used arrive at more predictive test tracks secretory capacity in relevant context. With development report context intended function, expand into widely accessible treatment option individuals diabetes.