Causing a commotion in the blood: immunotherapy progresses from bacteria to bacterial DNA
作者： Arthur M Krieg , Hermann Wagner
DOI: 10.1016/S0167-5699(00)01719-9
关键词:
摘要: Abstract The vertebrate immune system recognizes bacterial DNA as foreign based on its content of unmethylated CpG motifs. detection motifs by the innate induces responses that are strongly Th1-biased. These can be mimicked using synthetic oligonucleotides, which have shown significant effects vaccine adjuvants and immunotherapeutics for treatment cancer allergic conditions in model systems.
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Stephen S. Hall, A Commotion in the Blood: Life, Death, and the Immune System ,(1997)
Benjamin M. Segal, John T. Chang, Ethan M. Shevach, CpG Oligonucleotides Are Potent Adjuvants for the Activation of Autoreactive Encephalitogenic T Cells In Vivo Journal of Immunology. ,vol. 164, pp. 5683- 5688 ,(2000) , 10.4049/JIMMUNOL.164.11.5683
Dennis M. Klinman, Nilanjana Sur, Rafeul Alam, Barun K. Choudhury, Sanjiv Sur, James S. Wild, Long term prevention of allergic lung inflammation in a mouse model of asthma by CpG oligodeoxynucleotides. Journal of Immunology. ,vol. 162, pp. 6284- 6293 ,(1999)
Guo-Min Deng, Ing-Marie Nilsson, Margareta Verdrengh, L.Vincent Collins, Andrej Tarkowski, Intra-articularly localized bacterial DNA containing CpG motifs induces arthritis Nature Medicine. ,vol. 5, pp. 702- 705 ,(1999) , 10.1038/9554
E. Martin-Orozco, D. Broide, M.-D. Nguyen, H. Tighe, E. Raz, T. Gifford, S. Malek, J. Schwarze, E. W. Gelfand, J. Van Uden, Immunostimulatory DNA Sequences Inhibit IL-5, Eosinophilic Inflammation, and Airway Hyperresponsiveness in Mice Journal of Immunology. ,vol. 161, pp. 7054- 7062 ,(1998)
G S Gilkeson, J P Messina, D S Pisetsky, Stimulation of in vitro murine lymphocyte proliferation by bacterial DNA. Journal of Immunology. ,vol. 147, pp. 1759- 1764 ,(1991)
Gary A. Koretzky, Lyse A. Norian, Peggy S. Myung, Nancy J. Boerth, John S. Cowdery, Differential regulation of the IL-12 p40 promoter and of p40 secretion by CpG DNA and lipopolysaccharide. Journal of Immunology. ,vol. 162, pp. 6770- 6775 ,(1999)
W L Rasmussen, Z K Ballas, A M Krieg, Induction of NK activity in murine and human cells by CpG motifs in oligodeoxynucleotides and bacterial DNA. Journal of Immunology. ,vol. 157, pp. 1840- 1845 ,(1996)
Lori Manzel, Donald E. Macfarlane, Antagonism of Immunostimulatory CpG-Oligodeoxynucleotides by Quinacrine, Chloroquine, and Structurally Related Compounds Journal of Immunology. ,vol. 160, pp. 1122- 1131 ,(1998)
Laurie Love-Homan, John T. Harty, Arthur M. Krieg, Ae-Kyung Yi, CpG DNA Induces Sustained IL-12 Expression In Vivo and Resistance to Listeria monocytogenes Challenge Journal of Immunology. ,vol. 161, pp. 2428- 2434 ,(1998)