Cutaneous melanoma in women: ovulatory life, menopause, and use of exogenous estrogens.

摘要: Factors related to menopause and use of exogenous hormones other than p.o. contraceptives were examined in 452 women ages 25-59 who diagnosed with cutaneous malignant melanoma. Control subjects for this population-based study the San Francisco Bay Area 930 same age. An increased risk was observed superficial spreading melanoma (SSM) reached natural after age 55 [odds ratio (OR), 3.6; 95% confidence interval (CI), 1.1-11.1], had a bilateral oophorectomy within 9 years their diagnosis SSM (OR, 2.2; CI, 1.1-4.5). A somewhat elevated or hysterectomy no longer statistically significant adjustment hormone use. Prolonged retained at least one ovary associated an 5.4; 1.5-19.3), these products fewer 5 also 2.9; 1.0-7.8). Conjugated estrogen risks 2.7; 0.97-7.3) 2.1; 0.86-5.0). There suggestion trend dosage conjugated estrogens (P = 0.07). Use vaginal creams that contained 1.8; 1.0-3.3).