Reactive astrocytes express the embryonic intermediate neurofilament nestin

摘要: Nestin is a neurofilament protein expressed by the immediate precursors to neurons and glia in rats humans. immunoreactivity rat CNS was studied following kainic acid (KA) hippocampal lesions. Numerous nestin positive cells within KA lesion were confirmed be reactive astrocytes their for glial fibrillary acidic (GFAP). The number of these decreased with time after no astrocyte immunostaining observed control animals. A subset nestin-positive ventricular subependymal region appeared radial cells, extending cell body layers. one several embryonic markers astrocytes, suggesting an reversion induced lesion, possibly enhance functional recovery.