STC-1 Cells
作者： Triona McCarthy , Brian D. Green , Danielle Calderwood , Anna Gillespie , John F. Cryan
DOI: 10.1007/978-3-319-16104-4_19
关键词:
摘要: Gastrointestinal hormones such as cholecystokinin (CCK), glucagon like peptide 1 (GLP-1), and YY (PYY) play an important role in suppressing hunger controlling food intake. These satiety are secreted from enteroendocrine cells present throughout the intestinal tract. The secretin tumor cell line (STC-1) possesses many features of native cells. As such, STC-1 routinely used screening platforms to identify foods or compounds that modulate secretion gastrointestinal vitro. This chapter describes this model focussing on it’s applications, advantages limitations. A general protocol is provided for challenging with test compounds.
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