Cranberries and Cancer: An Update of Preclinical Studies Evaluating the Cancer Inhibitory Potential of Cranberry and Cranberry Derived Constituents
作者： Katherine M. Weh , Jennifer Clarke , Laura A. Kresty
DOI: 10.20944/PREPRINTS201608.0160.V2
关键词:
摘要: Cranberries are rich in bioactive constituents reported to influence a variety of health benefits, ranging from improved immune function and decreased infections reduced cardiovascular disease more recently cancer inhibition. A review cranberry research targeting revealed positive effects cranberries or derived against 17 different cancers utilizing vitro techniques, whereas vivo studies supported the inhibitory action toward esophagus, stomach, colon, bladder, prostate, glioblastoma lymphoma. Mechanisms cranberry-linked inhibition include cellular death induction via apoptosis, necrosis autophagy; reduction proliferation; alterations reactive oxygen species; modification cytokine signal transduction pathways. Given emerging preclinical cranberries, future clinical directions premalignancy high risk cohorts should be considered.
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