Extrinsic Factors Regulating Dendritic Patterning.

摘要: Stereotypic dendrite arborizations are key morphological features of neuronal identity, as the size, shape and location dendritic trees determine synaptic input fields how information is integrated within developed neural circuits. In this review, we focus on actions extrinsic intercellular communication factors their effects intrinsic developmental processes that lead to patterning. Surrounding neurons or supporting cells express adhesion receptors secreted proteins respectively, act via direct contact over short distances shape, localize dendrites during specific stages. The different ligand-receptor interactions downstream signaling events appear morphogenesis by converging two categorical mechanisms: local cytoskeletal modulation global transcriptional regulation growth components, such lipid synthesis enzymes. Recent work has begun uncover coordinated multiple promotes complexity in ensures robust