A comprehensive evaluation of the prognostic significance of 13q deletions in patients with B-chronic lymphocytic leukaemia.

摘要: Deletion 13q14 on fluorescence in situ hybridization (FISH) analysis is the most common cytogenetic abnormality chronic lymphocytic leukemia (CLL), and a favorable prognostic biomarker when detected as sole abnormality. We intensively interrogated clinical outcome 323 consecutive, untreated CLL patients with isolated 13q- identified within two years of diagnosis. also analyzed 217 additional deletion 11q22.3 or 17p13.1, trisomy 12 based whether these occurred isolation conjunction 13q-. Patients heterozygous those homozygous had similar time to first treatment (TFT) overall survival (OS). In contrast, higher percentage nuclei was associated significantly shorter TFT (p 65.5% (p<0.001). The exhibiting remained an independent predictor after controlling for ZAP-70, IgVH, CD38 (all p<0.001). Among plus one other FISH abnormality, concomitant appeared attenuate 17p- (p=0.019). implications appear more complex than originally appreciated.