Assessment of acetamiprid-induced genotoxic effects in bone marrow cells of Swiss albino male mice.
作者： Preeti Bagri , S. K. Jain
DOI: 10.1080/01480545.2018.1429461
关键词:
摘要: Acetamiprid (ACE), a neonicotinoid insecticide, is widely used in agriculture either alone or combination with other insecticides. A combined approach employing micronucleus test (MNT) and chromosomal aberrations (CA) assay was utilized to assess the genotoxic effects of ACE bone marrow Swiss albino male mice. administered i.p. daily at 4.6 2.3 mg/kg/day along 3% gum acacia as negative control for 60 90 days cyclophosphamide (50 mg/kg b.wt.) positive control. treatment resulted dose-dependent increase frequencies micronuclei per cell cells. The increased formation total erythrocyte cells (immature PCEs mature NCEs) observed only higher dose level (4.6 mg/kg 90 days. also indicated cytotoxic effect pesticide by PCE/NCE ratio. number were treated group compared group, although significant exposed both Thus, exposure 4.6 mg/kg body weight caused on somatic
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