Bruceines K and L from the Ripe Fruits of Brucea javanica
作者： Ming Zhao , Sin Ting Lau , Xiao Qi Zhang , Wen Cai Ye , Po Sing Leung
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摘要: Bruceine K (1), a pentacyclic C20-quassinoid bearing unique 12,20-epoxy moiety, and bruceine L (2), along with the ten known compounds (6S,7E)-6,9,10-trihydroxy- (6S,7E)-6,9-dihydroxymegastigma-4,7-dien-3-one (3 4, resp.), cleomiscosins A–C, luteoline, quercetine, bruceantinol, pinoresinol, thevetiaflavone, were isolated from ripe fruits of Brucea javanica. Bruceines (1) (2) determined to be (1β,2α,11β,12β,14ξ,15β)-12,20-epoxy-1,2,11,13,14,15-hexahydroxypicras-3-en-16-one (1β,2α,11β,12β,15β)-13,20-epoxy-1,2,11,12-tetrahydroxy-16-oxo-15-(senecioyloxy)picras-3-en-21-oic acid methyl ester (senecioic acid=3-methylbut-2-enoic acid), respectively, on basis NMR (1H- 13C-NMR, DEPT, 1H,1H-COSY, NOESY, HMQC, HMBC) ESI-MS data. Among compounds, cleomiscosin C, thevetiaflavone for first time plants.
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