Effect of morphine sulphate eye drops on hyperalgesia in the rat cornea.
作者： N H. Wenk , N M. Nannenga , N C. Honda
DOI: 10.1016/S0304-3959(03)00260-4
关键词:
摘要: In addition to their traditional role in centrally mediated analgesia, opiate compounds produce significant effects when administered peripherally. Using a recently characterized model of acute chemical injury the rat cornea, we assessed morphine sulphate eye drops on corneal inflammation and hyperalgesia. Topical application 5 microM drop preparation attenuated capsaicin-induced blinking concentration-dependent manner. However, had no effect applied healthy, non-inflamed cornea. addition, given every 2 h following cauterization retarded development both stromal edema infiltration immune cells. Both analgesic anti-inflammatory were prevented by opioid receptor antagonists naloxone, CTAP, naltrindole. We conclude that acts mu delta receptors located cornea attenuate
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