DNA self-fitting: the double helix directs the geometry of its supramolecular assembly

摘要: Groove-backbone interaction is a natural and biologically relevant mechanism for the specific assembly of B-DNA double helices. Crystal engineering crystal packing analysis oligonucleotides different sizes sequences reveal that sequence-dependent self-fitting helices dominant constraint their ordered assembly. It can override other intermolecular interactions impose overall geometry packing. Analysis experimental examples architectural motifs formed by geometric combination self-fitted DNA segments leads to general rules Like directing piece supramolecular 'construction set', helix imposes limited number solutions. These basic constraints could direct, in codified manner, formation higher-order structures. exhibit new structural electrostatic properties which have some implications molecular recognition proteins acting on DNA.