Antimicrobial resistances of extraintestinal pathogenic Escherichia coli isolates from swine in China

摘要: Abstract Antibiograms and relevant genotypes of porcine extraintestinal pathogenic Escherichia coli (ExPEC) isolates (n = 315) recovered between 2004 2007 in China were assessed. Among the 14 antimicrobials tested, most prevalent resistance was to ampicillin, trimethoprim, sulfadimidine, tetracycline, neomycin, streptomycin, kanamycin, ciprofloxacin ofloxacin (ranging from 81.9 100%). Forty-six multiresistant patterns found. For each antimicrobial agent, ampicillin primarily mediated by blaTEM, streptomycin strA strB, kanamycin/neomycin aphA1, gentamicin aac(3)-IV, quinolones mutations gyrA, tetracycline tet(A), tet(B) tet(G), trimethoprim dfrA7, dfrA12 dfrA13, sulfadimidine sul1 sul2. Both blaTEM-1 blaCTX-M-14 found two ESBLs-producing isolates. Strains that harbored several genes conferred same agent often significantly more than others. Class 1 integrons identified 86 (27.3%) ExPEC isolates, which dfrA14, aadA2, aadA22, dfrA17, aadA5, dfrA17-aadA2, dfrA1-aadA1, dfrA12-aadA2, dfrA17-aadA5 gene cassettes five major different variable regions, conferring aminoglycosides. These results provide novel insights into epidemiological characteristics strains China, suggest need for prudent use agents food animals.