Preparation and Characterization of ketoconazole encapsulated liposome and ethosome: A Comparative study.
作者： Gunjan Tiwari
DOI:
关键词:
摘要: Skin act as a major target well principle barrier for transdermal drug delivery. Vesicular system is one of the most promising approaches delivery active substances. Liposomes are commonly used vesicular system. But it has certain limitations such lesser stability, reduced encapsulation efficiency, etc led to formulation ethosomes. In present work we encapsulated various concentration ketoconazole (an antifungal drug) within ethosome and liposome made comparative evaluation their morphology, size, potential, stability anti-fungal efficacy. Ethosomes showed better efficiency activity compared due its ethanolic content. So ethosomal may prove very option potential new opportunities topical application in fungal infections.
参考文章(26)
T Kuennen, SMALL SCIENCE WILL BRING BIG CHANGES TO ROADS Better Roads. ,vol. 74, ,(2004)
K. Eric Drexler, Engines of Creation ,(1986)
Alastair J.J. Wood, Jackson A. Como, William E. Dismukes, Oral Azole Drugs as Systemic Antifungal Therapy The New England Journal of Medicine. ,vol. 330, pp. 263- 272 ,(1994) , 10.1056/NEJM199401273300407
A.D. Bangham, R.W. Horne, Negative staining of phospholipids and their structural modification by surface-active agents as observed in the electron microscope Journal of Molecular Biology. ,vol. 8, pp. 660- IN10 ,(1964) , 10.1016/S0022-2836(64)80115-7
Nava Dayan, Elka Touitou, Carriers for skin delivery of trihexyphenidyl HCl: ethosomes vs. liposomes. Biomaterials. ,vol. 21, pp. 1879- 1885 ,(2000) , 10.1016/S0142-9612(00)00063-6
Xueshen Wang, Qunqing Li, Jing Xie, Zhong Jin, Jinyong Wang, Yan Li, Kaili Jiang, Shoushan Fan, Fabrication of Ultralong and Electrically Uniform Single-Walled Carbon Nanotubes on Clean Substrates Nano Letters. ,vol. 9, pp. 3137- 3141 ,(2009) , 10.1021/NL901260B
Demetrios Papahadjopoulos, Harold K. Kimelberg, Phospholipid vesicles (liposomes) as models for biological membranes: Their properties and interactions with cholesterol and proteins Progress in Surface Science. ,vol. 4, pp. 141- 232 ,(1974) , 10.1016/S0079-6816(74)80006-7
Vaibhav Dubey, Dinesh Mishra, Tathagata Dutta, Manoj Nahar, DK Saraf, NK Jain, None, Dermal and transdermal delivery of an anti-psoriatic agent via ethanolic liposomes Journal of Controlled Release. ,vol. 123, pp. 148- 154 ,(2007) , 10.1016/J.JCONREL.2007.08.005
U. Ayanthi Gunasekera, Quentin A. Pankhurst, Michael Douek, Imaging applications of nanotechnology in cancer Targeted Oncology. ,vol. 4, pp. 169- 181 ,(2009) , 10.1007/S11523-009-0118-9
Y.-E. Rahman, M. W. Rosenthal, E. A. Cerny, Intracellular plutonium: removal by liposome-encapsulated chelating agent Science. ,vol. 180, pp. 300- 302 ,(1973) , 10.1126/SCIENCE.180.4083.300