The effect of Plasmodium vivax infection on SOCS gene expression in Anopheles dirus (Diptera: Culicidae).

作者: T Pengsakul , N Kongchouy , S Boonrotpong , A Ponlawat , N Nanakorn

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摘要: The Anopheles dirus mosquito is a primary malaria vector that transmits many species of Plasmodium parasites in Thailand and widely spread across its geographic area. In the current study, levels expression suppressor cytokine signaling (SOCS) gene An. mosquitoes infected with P. vivax were examined. level gene's determined by mRNA extraction females (n=2,400) was studied at different times (0, 12, 24, 36, 48 h after feeding), types blood feeding (non-feeding, parasite-negative feeding, parasite-positive feeding) parts body samples (thorax abdomen). datasets analyzed based on their relative ratio 2-ΔΔCT method tested for significant differences ANOVA. results showed SOCS stimulated abdomen 12 24 about three more highly than unfed females, difference being significant. At vivax-infected expressed almost 36 higher control group who not fed blood. However, thorax all non-feeding, there no gene. Therefore, most post-feeding bloodmeal, which indicates major plays an important role immune system response to infection.

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