Synthesis, Characterization and Biological Studies of Metal(II) Complexes of (3E)-3-[(2-{(E)-[1-(2,4-Dihydroxyphenyl) ethylidene]amino}ethyl)imino]-1-phenylbutan-1-one Schiff Base

摘要: Co(II), Ni(II), Zn(II) and Cu(II) complexes of (3E)-3-[(2-{(E)-[1-(2,4-dihydroxyphenyl)ethylidene]amino}ethyl)imino]-1-phenylbutan-1-one (DEPH2) derived from ethylenediamine, 2′,4′-dihydroxyacetophenone 1-phenylbutane-1,3-dione have been synthesized characterized by elemental analysis, FTIR, UV-Visible spectroscopy, screened to establish their potential as antibacterial agents, antioxidants DPPH radical scavengers. The FTIR spectra showed that the ligand behaves a dibasic tetradentate with dioxygen-dinitrogen donor atom system oriented towards central metal ion. analytical spectroscopic data suggest square planar geometry for Ni(II) an octahedral Co(II) complex. were activity against Gram (+) (−) bacteria agar well diffusion method. In addition, antioxidant activities also investigated through scavenging effect on ABTS radicals. obtained IC50 value copper complex (2.08 ± 0.47 µM) (IC50 = 2.11 + 1.69 higher than values other compounds.