Effects of preoperative administration of ketoprofen on whole blood platelet aggregation, buccal mucosal bleeding time, and hematologic indices in dogs undergoing elective ovariohysterectomy

摘要: Objective—To determine effects of preoperative administration ketoprofen on whole blood platelet aggregation, buccal mucosal bleeding time, and hematologic indices in dogs after elective ovariohysterectomy. Design—Randomized, masked clinical trial. Animals—22 healthy dogs. Procedure—60 minutes before induction anesthesia, 11 were given 0.9% NaCl solution (control), (2 mg/kg [0.9 mg/lb], IM). Thirty glycopyrrolate (0.01 [0.005 mg/lb]), acepromazine (0.05 [0.02 butorphanol (0.2 [0.09 mg/lb]) IM to all Anesthesia was induced with thiopental (5 10 [2.3 4.5 IV) maintained isoflurane (1 3%). Ovariohysterectomy performed (0.1 [0.05 15 completion surgery. Blood samples for measurement variables collected at intervals Results—In ketoprofen, pl...