Associations between the FAS -670 A/G and -1,377 G/A polymorphisms and susceptibility to autoimmune rheumatic diseases: a meta-analysis.

摘要: The aim of this study was to explore whether FAS −670 A/G and −1,377 G/A polymorphisms confer susceptibility autoimmune rheumatic diseases. A meta-analysis conducted on the associations between diseases using allele contrast, a recessive model, dominant an additive model. Thirteen articles with 21 comparison studies (16 5 polymorphisms) including systemic lupus erythematosus (SLE), four sclerosis, Sjogren’s syndrome, three rheumatoid arthritis (RA), one juvenile idiopathic arthritis, spondyloarthropathy were available for meta-analysis. Meta-analysis revealed association polymorphism in model (odds ratio [OR] = 0.761, 95 % confidence interval [CI] = 0.621–0.932, p = 0.008]. Stratification by ethnicity indicated −670 G carrier Asian (OR = 0.569, CI = 0.409–0.791, p = 0.001). Furthermore, stratification disease SLE RA (OR = 0.578, CI = 0.358–0.934, p = 0.025; OR = 0.609, CI = 0.398–0.934, p = 0.023, respectively). negatively associated susceptibility. stratified showed −1,377 (OR = 0.783, CI = 0.613–0.997, p = 0.047). Meta-analyses also significant (OR = 0.712, CI = 0.528–0.961, p = 0.027). This demonstrates that confers Asians RA, is