Monoamine oxidase A gene (MAOA) predicts behavioral aggression following provocation

作者: R. McDermott , D. Tingley , J. Cowden , G. Frazzetto , D. D. P. Johnson

DOI: 10.1073/PNAS.0808376106

关键词:

摘要: Monoamine oxidase A gene (MAOA) has earned the nickname “warrior gene” because it been linked to aggression in observational and survey-based studies. However, no controlled experimental studies have tested whether warrior actually drives behavioral manifestations of these tendencies. We report an experiment, synthesizing work psychology economics, which demonstrates that occurs with greater intensity frequency as provocation is experimentally manipulated upwards, especially among low activity MAOA (MAOA-L) subjects. In this study, subjects paid punish those they believed had taken money from them by administering varying amounts unpleasantly hot (spicy) sauce their opponent. There some evidence a main effect for genotype environment interaction, such less associated occurrence condition, but significantly predicts behavior high situation. This new genetic influences on punishment complicates characterizations humans “altruistic” punishers supports theories cooperation propose mixed strategies population. It also suggests important implications role individual variance factors contributing everyday behaviors decisions.

参考文章(41)
JC Shih, K Chen, MAO-A and -B gene knock-out mice exhibit distinctly different behavior. Neurobiology (Budapest, Hungary). ,vol. 7, pp. 235- ,(1999)
Dominique J-F De Quervain, Urs Fischbacher, Valerie Treyer, Melanie Schellhammer, Ulrich Schnyder, Alfred Buck, Ernst Fehr, The Neural Basis of Altruistic Punishment Science. ,vol. 305, pp. 1254- 1258 ,(2004) , 10.1126/SCIENCE.1100735
Avshalom Caspi, Terrie E. Moffitt, Gene–environment interactions in psychiatry: joining forces with neuroscience Nature Reviews Neuroscience. ,vol. 7, pp. 583- 590 ,(2006) , 10.1038/NRN1925
Holly A. McGregor, Joel D. Lieberman, Jeff Greenberg, Sheldon Solomon, Jamie Arndt, Linda Simon, Tom Pyszczynski, Terror management and aggression: evidence that mortality salience motivates aggression against worldview-threatening others. Journal of Personality and Social Psychology. ,vol. 74, pp. 590- 605 ,(1998) , 10.1037/0022-3514.74.3.590
D. Cesarini, C. T. Dawes, J. H. Fowler, M. Johannesson, P. Lichtenstein, B. Wallace, Heritability of cooperative behavior in the trust game Proceedings of the National Academy of Sciences of the United States of America. ,vol. 105, pp. 3721- 3726 ,(2008) , 10.1073/PNAS.0710069105
Lee A. Kirkpatrick, Christian E. Waugh, Alelhie Valencia, Gregory D. Webster, The functional domain specificity of self-esteem and the differential prediction of aggression. Journal of Personality and Social Psychology. ,vol. 82, pp. 756- 767 ,(2002) , 10.1037//0022-3514.82.5.756
B. Wallace, D. Cesarini, P. Lichtenstein, M. Johannesson, Heritability of ultimatum game responder behavior Proceedings of the National Academy of Sciences of the United States of America. ,vol. 104, pp. 15631- 15634 ,(2007) , 10.1073/PNAS.0706642104
Joel D. Lieberman, Sheldon Solomon, Jeff Greenberg, Holly A. McGregor, A hot new way to measure aggression: Hot sauce allocation Aggressive Behavior. ,vol. 25, pp. 331- 348 ,(1999) , 10.1002/(SICI)1098-2337(1999)25:5<331::AID-AB2>3.0.CO;2-1
T. H. Clutton-Brock, G. A. Parker, Punishment in animal societies. Nature. ,vol. 373, pp. 209- 216 ,(1995) , 10.1038/373209A0